Browsing by Author "Ojeda, Diego"

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    In vivo drug resistance mutation dynamics from the early to chronic stage of infection in antiretroviral‑therapy‑naïve HIV‑infected men who have sex with men
    (2020-9) Cevallos, Cintia; Culasso, Andrés C. A.; Urquiza, Javier; Ojeda, Diego; Sued, Omar; Figueroa, María I.; Avila, María M.; Delpino, M. Victoria; Quarleri, Jorge F.
    Human immunodeficiency virus type 1 (HIV) primary drug resistance mutations (DRMs) influence the long-term therapeutic effects of antiretroviral treatment (ART). Drug-resistance genotyping based on polymerase gene sequences obtained by next-generation sequencing (NGS) was performed using samples from 10 ART-naïve HIV-infected men who have sex with men (MSM; P1-P10) from the acute/early to chronic stage of infection. Three of the 10 subjects exhibited the presence of major (abundance, ≥ 20%) viral populations carrying DRM at early/acute stage that later, at the chronic stage, dropped drastically (V106M) or remained highly abundant (E138A). Four individuals exhibited additional DRMs (M46I/L; I47A; I54M, L100V) as HIV minority populations (abundance, 2-20%) that emerged during the chronic stage but ephemerally.