ICOS, SLAM and PD-1 expression and regulation on T lymphocytes reflect the immune dysregulation in patients with HIV-related illness with pulmonary tuberculosis

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dc.contributor.authorJurado, Jorge O.
dc.contributor.authorPasquinelli, Virginia
dc.contributor.authorAlvarez, Ivan B.
dc.contributor.authorMartínez, Griselda J.
dc.contributor.authorLaufer, Natalia
dc.contributor.authorSued, Omar
dc.contributor.authorCahn, Pedro
dc.contributor.authorMusella, Roberto M.
dc.contributor.authorAbbate, Esteban
dc.contributor.authorSalomon, Horacio
dc.contributor.authorQuiroga, Maria F.
dc.date.accessioned2024-05-23T18:53:32Z
dc.date.available2024-05-23T18:53:32Z
dc.date.issued2012
dc.description.abstractBackground: Tuberculosis (TB) continues to be the most frequent cause of illness and death from an infectious agent globally, and its interaction with HIV is having devastating effects. To investigate how HIV alters the immune response to Mycobacterium tuberculosis (Mtb), we assessed basal and Mtb-induced proliferation, cytokine production, and expression of signalling lymphocytic activation molecule (SLAM), inducible costimulator (ICOS) and programmed death-1 (PD-1) on T lymphocytes from HIV-positive individuals coinfected with TB, HIV-positive subjects, TB patients and healthy donors (HD). Findings: HIV-TB patients showed increased ICOS, SLAM and PD-1 basal levels on T lymphocytes, whereas HIV-positive individuals displayed elevated levels of SLAM and PD-1, TB patients high levels of SLAM, and HD low levels of the three proteins. Mtb-stimulation enhanced ICOS expression in the four groups, but only TB and HD increased SLAM and PD-1 levels. Conclusions: These data show the immune deregulation that takes place during the immune response against TB in different study populations.
dc.identifier.citationJurado, J. O., Pasquinelli, V., Alvarez, I. B., Martínez, G. J., Laufer, N., Sued, O., Cahn, P., Musella, R. M., Abbate, E., Salomon, H., & Quiroga, M. F. (2012). ICOS, SLAM and PD-1 expression and regulation on T lymphocytes reflect the immune dysregulation in patients with HIV-related illness with pulmonary tuberculosis. Journal of the International AIDS Society.
dc.identifier.otherDOI: 10.7448/IAS.15.2.17428
dc.identifier.urihttps://repositorio.huesped.org.ar/handle/123456789/1078
dc.relation.ispartofseriesJournal of the International AIDS Society
dc.subjectICOS expression
dc.subjectimmune dysregulation
dc.subjectpulmonary tuberculosis
dc.titleICOS, SLAM and PD-1 expression and regulation on T lymphocytes reflect the immune dysregulation in patients with HIV-related illness with pulmonary tuberculosis

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