HIV-1 infected patients older than 50 years. PISCIS cohort study

Navarro, Gemma; Nogueras, Maria M.; Segura, Ferran; Casabona, Jordi; Miro, Jose M.; Murillas, Javier; Tural, Cecilio; Ferrer, Enrique; Jaén, Amelia; Force, Laura; Vilaró, Laura; García, Iván; Masabeu, Antoni; Altés, José; Esteve, Albert; Sued, Omar; Riera, Maria; Clotet, Bonaventura; Podzamczer, Daniel; Gatell, Jose; PISCIS Study Group

HIV-1 infected patients older than 50 years. PISCIS cohort study

Date

2008

Authors

Abstract

Objective: The aim of this study is to characterize the ways in which older HIV-infected people differ from younger HIV-infected people. Methods: Prospective cohort study. PISCIS cohort includes newly attended HIV-infected subjects since January 1, 1998. Naive patients were selected. Two groups were defined: G1 (>or=50 years at time of diagnosis, n=493) and G2 (18-49 years, n=4511). Statistical analysis was performed using chi(2), Student's t test, Cox regression and linear mixed models. Results: G1 had different features: males (G1: 84% vs. G2: 75%, p<0.001), sexual transmission (52% vs. 32%, p<0.001), AIDS at first visit (38% vs. 22%, p<0.001). The follow-up was 6 years. Ninety-five percent of patients in G1 and 92% in G2 presented a detectable viral load (>or=500 copies/mm(3)) at the first visit (p=0.016). G1 presented lower CD4 levels with respect to G2 throughout the period but the increase of CD4 in G1 at the end of the study period was 254 cells/mm(3) whereas for G2 it was 196 cells/mm(3) (p<0.001). Mortality was 9% for G1 and 4% for G2 (p<0.001). Conclusions: HIV-infected people diagnosed at the age of 50 years or older showed different features. They showed good viral and immunological response to HAART.

Keywords

HIV-1 infected patients, PISCIS cohort study, older than 50 years

Citation

Navarro, G., Nogueras, M. M., Segura, F., Casabona, J., Miro, J. M., Murillas, J., ... Gatell, J. M. (2008). HIV-1 infected patients older than 50 years: PISCIS cohort study. Journal of Infection.