Determination of dehydroepiandrosterone and its biologically active oxygenated metabolites in human plasma evinces a hormonal imbalance during HIV-TB coinfection

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dc.contributor.authorVecchione, María Belén
dc.contributor.authorEiras, Javier
dc.contributor.authorSuarez, Guadalupe Verónica
dc.contributor.authorAngerami, Matías Tomás
dc.contributor.authorMarquez, Cecilia
dc.contributor.authorSued, Omar
dc.contributor.authorBen, Graciela
dc.contributor.authorPérez, Héctor Miguel
dc.contributor.authorGonzalez, Diego
dc.contributor.authorMaidana, Patricia
dc.contributor.authorMesch, Viviana
dc.contributor.authorQuiroga, María Florencia
dc.contributor.authorBruttomesso, Andrea Claudia
dc.date.accessioned2024-05-23T23:49:57Z
dc.date.available2024-05-23T23:49:57Z
dc.date.issued2018-04-27
dc.descriptionFil: Sued O. Fundación Huésped, Buenos Aires; Argentinaes_ES
dc.description.abstractAn estimated one third of the world’s population is affected by latent tuberculosis (TB), which once active represents a leading cause of death among infectious diseases. Human immunodeficiency virus (HIV) infection is a main predisposing factor to TB reactivation. Individuals HIV-TB co-infected develop a chronic state of inflammation associated with hypothalamic-pituitary-adrenal (HPA) axis dysregulation. This results in a hormonal imbalance, disturbing the physiological levels of cortisol and dehydroepiandrosterone (DHEA). DHEA and its oxygenated metabolites androstenediol (AED), androstenetriol (AET) and 7-oxo-DHEA are immunomodulatory compounds that may regulate physiopathology in HIV-TB co-infection. In order to study possible changes in plasma levels of these hormones, we developed an approach based on high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). To our knowledge, this represents the first report of their simultaneous measurement in HIV-TB individuals and the comparison with healthy donors, obtaining statistically higher plasma levels of DHEA, AET and 7-oxo-DHEA in patients. Moreover, we found that concentrations of 7-oxo-DHEA positively correlated with absolute CD4+ T cell counts, nadir CD4+ T cell values and with individuals who presented TB restricted to the lungs. This research contributes to understanding the role of these hormones in HIV-TB and emphasizes the importance of deepening their study in this context.es_ES
dc.formatapplication/pdfes_ES
dc.identifier.doihttps://doi.org/10.1038/s41598-018-24771-8
dc.identifier.urihttps://repositorio.huesped.org.ar/handle/123456789/1410
dc.languageENGes_ES
dc.provenancePublishedes_ES
dc.relation.ispartofseriesScientific Reports;8, Article number: 6692 (2018)
dc.rightsopenAccesses_ES
dc.subjectDehydroepiandrosteronees_ES
dc.subjectHIVes_ES
dc.titleDetermination of dehydroepiandrosterone and its biologically active oxygenated metabolites in human plasma evinces a hormonal imbalance during HIV-TB coinfectiones_ES
dc.typeArticuloes_ES

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