Acute meningoencephalitis due to human immunodeficiency virus type 1 infection in 13 patients: Clinical description and follow-up

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dc.contributor.authorVillar del Saz, Sergi
dc.contributor.authorSued, Omar
dc.contributor.authorFalcó, Vicenç
dc.contributor.authorAgüero, Francisco
dc.contributor.authorCrespo, Manuel
dc.contributor.authorPumarola, Teresa
dc.contributor.authorCurran, Andrea
dc.contributor.authorGatell, Jose
dc.contributor.authorPahissa, Alberto
dc.contributor.authorMiro, Jose M.
dc.contributor.authorRibera, Esteban
dc.date.accessioned2024-05-23T18:53:34Z
dc.date.available2024-05-23T18:53:34Z
dc.date.issued2008
dc.description.abstractThe objective of this study is to describe a series of cases of severe meningitis caused by human immunodeficiency virus type 1 (HIV-1) occurring during primary infection or after antiretroviral treatment interruption. In an observational cohort study, 13 patients with clinical diagnosis of meningitis or meningoencephalitis were reviewed. Ten cases occurred during primary HIV-1 infection and 3 after antiretroviral therapy (ART) withdrawal. Demographic parameters, clinical presentation and outcome, and laboratory and cerebrospinal fluid (CSF) parameters were recorded. The risk factor for HIV-1 infection acquisition was sexual transmission in all cases. The most frequent systemic symptoms were fever (12/13) and headeache (9/13). Among neurologic symptoms, focal signs appeared in seven patients (53.8%), confusion in six (46.2%), and agitation in five (38.5%). The median CD4 cell count was 434 cells/mm3. In all cases, CSF was a clear lymphocytaire fluid with normal glucose levels. Cranial computerized tomography was performed in seven patients, with a normal result in all of them; brain magnetic resonance in eight patients was normal in five cases and showing cortical atrophy, limbic encephalitis, and leptomeningeal enhancement in one patient each. The electroencephalographs (EEG) just showed diffuse dysfunction in three cases. ART was started in 11 patients. HIV RNA load at 12 months was <50 copies/ml in all treated patients. The 13 patients recovered without neurologic sequela. Meningitis or meningoencephalitis during primary HIV-1 infection or after ART cessation are unusual but sometimes a life-threatening manifestation. Although all patients tend to recover and the necessity of ART is not well established, some data suggest its potential benefit in these patients.
dc.identifier.citationSaz, S. V. del, Sued, O., Falcó, V., Agüero, F., Crespo, M., Pumarola, T., ... Miro´Ribera, E. (2008). Acute meningoencephalitis due to human immunodeficiency virus type 1 infection in 13 patients: Clinical description and follow-up. Journal of Neurovirology.
dc.identifier.otherDOI: 10.1080/13550280802195367
dc.identifier.urihttps://repositorio.huesped.org.ar/handle/123456789/1120
dc.relation.ispartofseriesJournal of NeuroVirology
dc.subjectAcute meningoencephalitis
dc.subjectHIV type 1
dc.subjectClinical description
dc.subjectFollow-up
dc.titleAcute meningoencephalitis due to human immunodeficiency virus type 1 infection in 13 patients: Clinical description and follow-up

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