Cancer in HIV-Infected Persons From the Caribbean, Central and South America

Simple item page
dc.contributor.authorFink, Valeria
dc.contributor.authorShepherd, Bryan E.
dc.contributor.authorCesar, Carina
dc.contributor.authorKrolewiecki, Alejandro J.
dc.contributor.authorWehbe, Francisco
dc.contributor.authorCortes, Claudia
dc.contributor.authorCrabtree-Ramirez, Brenda
dc.contributor.authorPadgett, Denis
dc.contributor.authorShafaee, Mehdi
dc.contributor.authorSchechter, Mauro
dc.contributor.authorGotuzzo, Eduardo
dc.contributor.authorBacon, Melanie
dc.contributor.authorMcGowan, Catherine C.
dc.contributor.authorCahn, Pedro
dc.contributor.authorMasys, Daniel R.
dc.contributor.authorCaribbean Central South America Network for HIV Research Collaboration of the International Epidemiologic Databases to Evaluate AIDS Program
dc.date.accessioned2024-05-23T18:53:33Z
dc.date.available2024-05-23T18:53:33Z
dc.date.issued2011
dc.description.abstractBackground: HIV-infected individuals have heightened cancer risk. With the advent of highly active antiretroviral therapy (HAART), the frequency of some AIDS-defining cancers (ADC) has decreased although certain non-AIDS-defining cancers (NADC) are becoming more frequent. Cancers among HIV-infected individuals in Latin American and the Caribbean have not yet been carefully studied. Methods: Cancer cases among the Caribbean, Central and South American network for HIV Research (CCASAnet) cohort were identified reviewing clinical records and pre-existing databases. Results: There were 406 cancers reported: 331 ADC (224 Kaposi sarcomas and 98 non Hodgkin lymphomas). Most frequent NADC (n = 75) were Hodgkin lymphoma and skin cancers. Seventy-three percent of NADC and 45% of ADC were diagnosed >1 year after HIV diagnosis. Fifty-six percent of ADC occurred before HAART start. Median time from HAART start until cancer diagnosis was 2.5 years for NADC and 0.5 years for ADC (P = <0.001). Within 3372 HAART starters, 158 were diagnosed with 165 cancers (82.4% ADC); 85 cases were previous to or concomitant with HAART initiation. Incidence of cancer after HAART initiation in 8080 person-years of follow-up was 7.2 per 1000 person-years (95% confidence interval = 5.5 to 9.3) for ADC and 2.7 (95% confidence interval = 1.8 to 4.1) for NADC; incidence was higher in the first 2 months, particularly for ADC (47.6). A pre-HAART ADC was a predictor of mortality after adjusting for age, sex, and CD4 at HAART initiation. Conclusions: ADC were the most frequent cancers in this region and were often diagnosed close to HIV diagnosis and HAART start. Incidence of cancer was highest around HAART initiation.
dc.identifier.citationFink, V., Shepherd, B. E., Cesar, C., Krolewiecki, A. J., Wehbe, F., Cortes, C. P., ... Cahn, P. (2011). Cancer in HIV-infected persons from the Caribbean, Central and South America. Journal of Acquired Immune Deficiency Syndromes, 56(5), 467-473.
dc.identifier.other2011;56:467–473
dc.identifier.urihttps://repositorio.huesped.org.ar/handle/123456789/1093
dc.relation.ispartofseriesJournal of Acquired Immune Deficiency Syndrome
dc.subjectCancer
dc.subjectHIV-Infected Persons
dc.subjectCaribbean, Central, South America
dc.titleCancer in HIV-Infected Persons From the Caribbean, Central and South America

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
141_2011_Fink_Cancer is HIV- infected Persons from the Caribbean. Central and South America.pdf
Size:
121.26 KB
Format:
Adobe Portable Document Format
Download

Collections

Articulos científicos