Antiretroviral therapy and Kaposi’s sarcoma trends and outcomes among adults with HIV in Latin America

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dc.contributor.authorCastilho, Jessica L
dc.contributor.authorKim, Ahra
dc.contributor.authorJenkins, Cathy a
dc.contributor.authorGrinsztejn, Beatriz
dc.contributor.authorGotuzzo, Eduardo
dc.contributor.authorFink, Valeria
dc.contributor.authorPadgett, Denis
dc.contributor.authorBelaunzaran-Zamudio, Pablo F
dc.contributor.authorCrabtree-Ramírez, Brenda
dc.contributor.authorEscuder, Maria Mercedes
dc.contributor.authorSouza, Rosa Alencar
dc.contributor.authorTenore, Simone B
dc.contributor.authorPimentel, Sidnei R
dc.contributor.authorRodrigues Ikeda, Maria Letícia
dc.contributor.authorde Alencastro, Paulo R
dc.contributor.authorTupinanbas, Unai
dc.contributor.authorBrites, Carlos
dc.contributor.authorLuz, Estela
dc.contributor.authorNetto, Juliana
dc.contributor.authorCortes, Claudia
dc.contributor.authorGrangeiro, Alexandre
dc.contributor.authorShepherd, Bryan E
dc.contributor.authorMcGowan, Catherine C
dc.contributor.authorThe Caribbean, Central, South America network for HIV Epidemiology (CCASAnet)
dc.date.accessioned2024-05-23T23:49:15Z
dc.date.available2024-05-23T23:49:15Z
dc.date.issued2021-01-06
dc.descriptionFil: Castilho JL. Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN; USAes_ES
dc.description.abstractAbstract Introduction Kaposi’s sarcoma (KS) remains the most frequent malignancy in persons living with HIV (PWH) in Latin America. We examined KS trends and outcomes from Latin American clinical sites in the era of increased access to antiretroviral therapy (ART). Methods Cohorts in Brazil, Peru, Mexico, Honduras, Argentina and Chile contributed clinical data of PWH ≥16 years old from 2000 to 2017, excluding patients with KS diagnosed before clinic enrolment. We compared KS incidence over time using multivariable incidence rate ratios. Predictors of KS before/at or after ART initiation and of mortality after KS were examined using Cox regression. Results Of 25 981 PWH, 481 had incident KS, including 200 ART-naïve and 281 ART-treated patients. From 2000 to 2017, the incidence of KS decreased from 55.1 to 3.0 per 1000 person-years. In models adjusting for CD4 and other factors, the relative risk for KS decreased from 2000 to 2008. Since 2010, the adjusted risk of KS increased in the periods before and ≤90 days after ART initiation but decreased >90 days after ART. In addition to low CD4 and male-to-male sex, KS risk after ART was associated with age and history of other AIDS-defining illnesses. Mortality after KS (approximately 25% after five years) was not associated with either year of KS diagnosis nor timing of diagnosis relative to ART initiation. Conclusions KS incidence in Latin America has remained stable in recent years and risk is highest before and shortly after ART initiation. Early diagnosis of HIV and ART initiation remain critical priorities in the region.es_ES
dc.formatapplication/pdfes_ES
dc.identifier.doihttps://doi.org/10.1002/jia2.25658
dc.identifier.urihttps://repositorio.huesped.org.ar/handle/123456789/1331
dc.languageENGes_ES
dc.provenancePublishedes_ES
dc.relation.ispartofseriesJournal of the International AIDS Society;2021 Jan;24(1):e25658.
dc.rightsopenAccesses_ES
dc.titleAntiretroviral therapy and Kaposi’s sarcoma trends and outcomes among adults with HIV in Latin Americaes_ES
dc.typeArticuloes_ES

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