Hepatitis C Virus (HCV) Clearance After Treatment With Direct-Acting Antivirals in Human Immunodeficiency Virus (HIV)-HCV Coinfection Modulates Systemic Immune Activation and HIV Transcription on Antiretroviral Therapy

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dc.contributor.authorGhiglione, Yanina
dc.contributor.authorPolo, María Laura
dc.contributor.authorUrioste, Alejandra
dc.contributor.authorRhodes, Ajantha
dc.contributor.authorCzernikier, Alejandro
dc.contributor.authorTrifone, César
dc.contributor.authorFlorencia Quiroga, María
dc.contributor.authorSisto, Alicia
dc.contributor.authorPatterson, Patricia
dc.contributor.authorSalomon, Horacio
dc.contributor.authorRolón, María José
dc.contributor.authorBakkour, Sonia
dc.contributor.authorLewin, Sharon R
dc.contributor.authorTurk, Gabriela
dc.contributor.authorLaufer, Natalia
dc.date.accessioned2024-05-23T23:49:40Z
dc.date.available2024-05-23T23:49:40Z
dc.date.issued2020-04-02
dc.descriptionFil: Ghiglione Y. CONICET-Universidad de Buenos Aires, Instituto de Investigaciones Biomédicas en Retrovirus y Sida (INBIRS), Buenos Aires; Argentinaes_ES
dc.description.abstracthttps://doi.org/10.1093/ofid/ofaa115es_ES
dc.description.abstractBackground Hepatitis C virus (HCV) coinfection among people with human immunodeficiency virus (HIV) might perturb immune function and HIV persistence. We aimed to evaluate the impact of HCV clearance with direct-acting antivirals (DAAs) on immune activation and HIV persistence in HIV/HCV-coinfected individuals on antiretroviral therapy (ART). Methods In a prospective observational study, ART-treated participants with HIV/HCV coinfection received sofosbuvir/daclatasvir ± ribavirin (n = 19). Blood samples were collected before DAA therapy, at the end of treatment, and 12 months after DAA termination (12MPT). T- and natural killer (NK)-cell phenotype, soluble plasma factors, cell-associated (CA)-HIV deoxyribonucleic acid (DNA) forms (total, integrated, 2LTR), CA-unspliced (US) and multiple-spliced ribonucleic acid (RNA), and plasma HIV RNA were evaluated. Results Hepatitis C virus clearance was associated with (1) a downmodulation of activation and exhaustion markers in CD4+, CD8+ T, and NK cells together with (2) decreased plasma levels of Interferon gamma-induced protein 10 (IP10), interleukin-8 (IL-8), soluble (s)CD163 and soluble intercellular adhesion molecule (sICAM). Cell-associated US HIV RNA was significantly higher at 12MPT compared to baseline, with no change in HIV DNA or plasma RNA. Conclusions Elimination of HCV in HIV/HCV-coinfected individuals alters immune function and the transcriptional activity of latently infected cells. This report provides insights into the effects of HCV coinfection in HIV persistence and regards coinfected subjects as a population in which HIV remission might prove to be more challenging.
dc.formatapplication/pdfes_ES
dc.identifier.doihttps://doi.org/10.1093/ofid/ofaa115
dc.identifier.urihttps://repositorio.huesped.org.ar/handle/123456789/1386
dc.languageENGes_ES
dc.provenancePublishedes_ES
dc.relation.ispartofseriesOpen Forum Infectious Diseases;2020 Apr 2;7(5):20
dc.rightsopenAccesses_ES
dc.subjectHepatitis Ces_ES
dc.subjectHIVes_ES
dc.titleHepatitis C Virus (HCV) Clearance After Treatment With Direct-Acting Antivirals in Human Immunodeficiency Virus (HIV)-HCV Coinfection Modulates Systemic Immune Activation and HIV Transcription on Antiretroviral Therapyes_ES
dc.typeArticuloes_ES

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