Early Gag Immunodominance of the HIV-Specific T-Cell Response during Acute/Early Infection Is Associated with Higher CD8(+) T-Cell Antiviral Activity and Correlates with Preservation of the CD4(+) T-Cell Compartment

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dc.contributor.authorTurk, Gabriela
dc.contributor.authorGhiglione, Yanina
dc.contributor.authorFalivene, Juliana
dc.contributor.authorSocias, Maria E.
dc.contributor.authorLaufer, Natalia
dc.contributor.authorColoccini, Romina.
dc.contributor.authorRodriguez, Ana María
dc.contributor.authorRuiz, Maria
dc.contributor.authorPando, María
dc.contributor.authorGiavedoni, Luis
dc.contributor.authorCahn, Pedro
dc.contributor.authorSued, Omar
dc.contributor.authorSalomon, Horacio
dc.contributor.authorGherardi, María
dc.date.accessioned2024-05-23T15:24:12Z
dc.date.available2024-05-23T15:24:12Z
dc.date.issued2013
dc.description.abstractThe important role of the CD8+ T-cell response on HIV control is well established. Moreover, the acute phase of infection represents a proper scenario to delineate the antiviral cellular functions that best correlate with control. Here, multiple functional aspects (specificity, ex vivo viral inhibitory activity [VIA] and polyfunctionality) of the HIV-specific CD8+ T-cell subset arising early after infection, and their association with disease progression markers, were examined. Blood samples from 44 subjects recruited within 6 months from infection (primary HIV infection [PHI] group), 16 chronically infected subjects, 11 elite controllers (EC), and 10 healthy donors were obtained. Results indicated that, although Nef dominated the anti-HIV response during acute/early infection, a higher proportion of early anti-Gag T cells correlated with delayed progression. Polyfunctional HIV-specific CD8+ T cells were detected at early time points but did not associate with virus control. Conversely, higher CD4+ T-cell set points were observed in PHI subjects with higher HIV-specific CD8+ T-cell VIA at baseline. Importantly, VIA levels correlated with the magnitude of the anti-Gag cellular response. The advantage of Gag-specific cells may result from their enhanced ability to mediate lysis of infected cells (evidenced by a higher capacity to degranulate and to mediate VIA) and to simultaneously produce IFN-γ. Finally, Gag immunodominance was associated with elevated plasma levels of interleukin 2 (IL-2) and macrophage inflammatory protein 1β (MIP-1β). All together, this study underscores the importance of CD8+ T-cell specificity in the improved control of disease progression, which was related to the capacity of Gag-specific cells to mediate both lytic and nonlytic antiviral mechanisms at early time points postinfection.
dc.identifier.citationTurk, G., Ghiglione, Y., Falivene, J., Socias, M. E., Laufer, N., Coloccini, R. S., ... & Gherardi, M. M. (2013). Early Gag immunodominance of the HIV-specific T-cell response during acute/early infection is associated with higher CD8+ T-cell antiviral activity and correlates with preservation of the CD4+ T-cell compartment. Journal of Virology.
dc.identifier.otherDOI: 10.1128/JVI.00865-13
dc.identifier.urihttps://repositorio.huesped.org.ar/handle/123456789/1060
dc.relation.ispartofseriesJournal of Virology
dc.subjectT-cell response
dc.subjectAcute HIV infection
dc.subjectImmune preservation
dc.titleEarly Gag Immunodominance of the HIV-Specific T-Cell Response during Acute/Early Infection Is Associated with Higher CD8(+) T-Cell Antiviral Activity and Correlates with Preservation of the CD4(+) T-Cell Compartment

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