Macrophage HIV-1 infection in duodenal tissue of patients on long term HAART

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dc.contributor.authorZalar, Alberto
dc.contributor.authorFigueroa, Maria Ines
dc.contributor.authorRuibal-Ares, Beatriz
dc.contributor.authorBaré, Patricia
dc.contributor.authorCahn, Pedro
dc.contributor.authorBracco, Maria Marta
dc.contributor.authorBelmonte, Liliana
dc.date.accessioned2024-05-23T18:53:33Z
dc.date.available2024-05-23T18:53:33Z
dc.date.issued2010
dc.description.abstractMucosal surfaces play a major role in human immunodeficiency virus type 1 (HIV-1) transmission and pathogenesis. Since the role of intestinal macrophages as viral reservoirs during chronic HIV-1 infection has not been elucidated, we investigated the effects of successful therapy on intestinal HIV-1 persistence. Intestinal macrophage infection was demonstrated by the expression of p24 antigen by flow cytometry and by the presence of proviral DNA, assessed by PCR. Proviral DNA was detected in duodenal mucosa of HIV-infected patients under treatment with undetectable plasma viral load. These findings confirm that intestinal macrophages can act as viral reservoirs and permit HIV-1 production even after viral suppression following antiretroviral therapy.
dc.identifier.citationZalar, A., Figueroa, M. I., Ruibal-Ares, B., Baré, P., Cahn, P., & Belmonte, L. (2010). Macrophage HIV-1 infection in duodenal tissue of patients on long term HAART. Antiviral Research.
dc.identifier.otherDOI: 10.1016/j.antiviral.2010.05.005
dc.identifier.urihttps://repositorio.huesped.org.ar/handle/123456789/1103
dc.relation.ispartofseriesAntiviral Research
dc.subjectMacrophage HIV-1 infection
dc.subjectDuodenal tissue
dc.subjectLong term HAART
dc.titleMacrophage HIV-1 infection in duodenal tissue of patients on long term HAART

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