Discontinuation of maintenance therapy for cryptococcal meningitis in patients with AIDS treated with highly active antiretroviral therapy: an international observational study

Simple item page
dc.contributor.authorMussini, Cristina
dc.contributor.authorPezzotti, Patrizio
dc.contributor.authorMiró, José M
dc.contributor.authorMartinez, Esteban
dc.contributor.authorde Quiros, Juan Carlos Lopez Bernaldo
dc.contributor.authorCinque, Paola
dc.contributor.authorBorghi, Vanni
dc.contributor.authorBedini, Andrea
dc.contributor.authorDomingo, Pere
dc.contributor.authorCahn, Pedro
dc.contributor.authorBossi, Philippe
dc.contributor.authorde Luca, Andrea
dc.contributor.authord'Arminio Monforte, Antonella
dc.contributor.authorNelson, Mark
dc.contributor.authorNwokolo, Nneka
dc.contributor.authorHelou, Silvia
dc.contributor.authorNegroni, Ricardo
dc.contributor.authorJacchetti, Gaia
dc.contributor.authorSpinello, Antinori
dc.contributor.authorLazzarin, Adriano
dc.contributor.authorCossarizza, Andrea
dc.contributor.authorEsposito, Roberto
dc.contributor.authorAntinori, Andrea
dc.contributor.authorAberg, Judith A
dc.contributor.authorInternational Working Group on Cryptococcosis
dc.date.accessioned2024-05-23T23:49:34Z
dc.date.available2024-05-23T23:49:34Z
dc.date.issued2004-02-15
dc.descriptionFil: Cahn P. Fundación Huésped, Buenos Aires; Argentinaes_ES
dc.description.abstractWe conducted a retrospective, multicenter study evaluating the safety of discontinuing maintenance therapy for cryptococcal meningitis after immune reconstitution. Inclusion criteria were a previous definitive diagnosis of cryptococcal meningitis, a CD4 cell count of >100 cells/µL while receiving highly active antiretroviral therapy (HAART), and the subsequent discontinuation of maintenance therapy for cryptococcal meningitis. The primary end point was relapse of cryptococcal disease. As of July 2002, 100 patients were enrolled. When maintenance therapy was discontinued, the median CD4 cell count was 259 cells/µL and the median plasma virus load was <2.30 log10 copies/mL, and serum cryptococcal antigen was undetectable in 56 patients. During a median follow-up period of 28.4 months (range, 6.7–64.5; 262 person-years), 4 events were observed (incidence, 1.53 events per 100 person-years; 95% confidence interval, 0.42–3.92). Three of these patients had a CD4 cell count of >100 cells/µL and a positive serum cryptococcal antigen test result during the recurrent episode. In conclusion, discontinuation of maintenance therapy for cryptococcal meningitis is safe if the CD4 cell count increases to >100 cells/µL while receiving HAART. Recurrent cryptococcal infection should be suspected in patients whose serum cryptococcal antigen test results revert back to positive after discontinuation of maintenance therapy.es_ES
dc.formatapplication/pdfes_ES
dc.identifier.doihttps://doi.org/10.1086/381261
dc.identifier.urihttps://repositorio.huesped.org.ar/handle/123456789/1373
dc.languageENGes_ES
dc.provenancePublishedes_ES
dc.relation.ispartofseriesClinical Infectious Diseases;2004 Feb 15;38(4):565–71
dc.rightsopenAccesses_ES
dc.subjectAcquired Immunodeficiency Syndromees_ES
dc.subjectAntiretroviral Therapy, Highly Activees_ES
dc.subjectMeningitis, Cryptococcales_ES
dc.subjectImmune Reconstitutiones_ES
dc.titleDiscontinuation of maintenance therapy for cryptococcal meningitis in patients with AIDS treated with highly active antiretroviral therapy: an international observational studyes_ES
dc.typeArticuloes_ES

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
10.1086_381261.pdf
Size:
129.77 KB
Format:
Adobe Portable Document Format
Description:
10.1086/381261_eng
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Plain Text
Description:
Download

Collections

Articulos científicos