Determinants of Treatment Access in a Population-based Cohort of HIV-positive Men and Women Living in Argentina

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dc.contributor.authorZala, Carlos
dc.contributor.authorRustad, Clare A
dc.contributor.authorChan, Keith
dc.contributor.authorKhan, Nabeela I
dc.contributor.authorBeltran, Marcelo
dc.contributor.authorWarley, Eduardo
dc.contributor.authorCeriotto, Mariana
dc.contributor.authorDruyts, Eric F
dc.contributor.authorHogg, Robert S
dc.contributor.authorMontaner, Julio
dc.contributor.authorCahn, Pedro
dc.contributor.authorPUMA Study Group
dc.date.accessioned2024-03-05T02:39:47Z
dc.date.available2024-03-05T02:39:47Z
dc.date.issued2008-04-02
dc.descriptionFil: Cahn P. Fundación Huésped, Buenos Aires; Argentinaes_ES
dc.description.abstractObjective To report emerging data on the use of highly active antiretroviral therapy (HAART) in Argentina by assessing patterns of HAART access and late vs early treatment initiation in a population-based cohort of adults infected with HIV type-1. Design The Prospective Study on the Use and Monitoring of Antiretroviral Therapy (PUMA) is a study of 883 HIV-positive individuals enrolled in the Argentinean drug treatment program. Individuals were 16 years of age and older and were recruited from 10 clinics across Argentina. Methods Sociodemographic and clinical characteristics were examined using contingency tables (Pearson chi-square test and Fisher exact test) for categoric variables and Wilcoxon rank-sum test for continuous variables. To analyze time to initiation of HAART we used Kaplan-Meier methods and Cox regression. Results Patients who initiated HAART were more likely to be older, have an AIDS-defining illness, be an injection drug user (IDU), have a lower median CD4 cell count, have a higher median viral load, and be less likely to be men who have sex with men (MSM). In multivariate analysis, AIDS-defining illness and plasma viral load were significantly associated with time to starting therapy. Patients who received late access were more likely to be diagnosed with AIDS and have higher median plasma viral loads than those receiving early access. Conclusion Our results indicate that despite free availability of treatment, monitoring, and care in Argentina, a significant proportion of men and women are accessing HAART late in the course of HIV disease. Further characterization of the HIV-positive population will allow for a more comprehensive evaluation of the impact of HAART within the Argentinean drug treatment program.es_ES
dc.formatapplication/pdfes_ES
dc.identifier.doihttps://doi.org/10.1186/1758-2652-10-4-78
dc.identifier.urihttps://repositorio.huesped.org.ar/handle/123456789/293
dc.languageENGes_ES
dc.provenancePublishedes_ES
dc.relation.ispartofseriesJournal of the International AIDS Society;2008 Apr;10(1):78
dc.rightsopenAccesses_ES
dc.subjectHIVes_ES
dc.subjectArgentinaes_ES
dc.titleDeterminants of Treatment Access in a Population-based Cohort of HIV-positive Men and Women Living in Argentinaes_ES
dc.typeArticuloes_ES

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