Primary human immunodeficiency virus type 1 infection: clinical, virological and immunological characteristics of 75 patients (1997-2003)

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dc.contributor.authorSued, Omar
dc.contributor.authorMiro, Jose M.
dc.contributor.authorAlquezar, Antonio
dc.contributor.authorClaramonte, Xavier
dc.contributor.authorGarcía, Francesc
dc.contributor.authorPlana, Marta
dc.contributor.authorArnedo, Montserrat
dc.contributor.authorde Lazzari, Emilia
dc.contributor.authorGil, Carlos
dc.contributor.authorManzardo, Christian
dc.contributor.authorBlanco, Juan L.
dc.contributor.authorMartínez, Esteban
dc.contributor.authorMallolas, Josep
dc.contributor.authorJoseph, Jordi
dc.contributor.authorPumarola, Tomas
dc.contributor.authorGallart, Teresa
dc.contributor.authorGatell, Jose
dc.date.accessioned2024-05-23T18:53:35Z
dc.date.available2024-05-23T18:53:35Z
dc.date.issued2006
dc.description.abstractObjectives: To describe the epidemiological and clinical characteristics and the evolution of a cohort of patients with primary HIV-1 infection from the Barcelona area. Methods: Prospective cohort study of HIV-infected patients diagnosed with primary HIV infection in a tertiary hospital in Barcelona (Spain) from 1997 through 2003. Descriptive analysis of epidemiological and clinical characteristics and effect of highly active antiretroviral treatment (HAART) on outcome. Results: A total of 75 patients were diagnosed, accounting for 2.9% of the total of newly diagnosed HIV patients during the same time period. Eighty-one percent of the patients were males and the median age was 30 years (IQR 26-38). The most frequent transmission route was homosexual (72%), followed by heterosexual (17%) and intravenous drug abuse (11%). Seventy-seven percent of patients presented symptoms, the most frequent being fever (98%), asthenia (86%), arthralgia-myalgia (65%), lymphadenopathy (55%), night sweats (48%) and rash. Sixty-five percent started HAART, although the proportion of patients that received HAART decreased from 79% during the period 1997-2000 to 49% during the period 2001-2003 (p < 0.01). After a median follow-up of 37 months (IQR 26-66), one patient died and eight cases were lost to follow-up. The patients who did not receive HAART had a higher probability of immunological or clinical deterioration during the follow-up when compared to the group that received HAART (42.3% versus 12.3%; p < 0.001). In treated patients, dyslipidemia and lipodystrophy were diagnosed in 58% and 37% of cases, respectively. Conclusions: Primary HIV-1 infection was diagnosed more frequently in homosexual males, and its clinical characteristics were similar to those observed in previous studies. HAART given during primary HIV infection was effective, but was associated with a high percentage of adverse effects.
dc.identifier.citationSued, O., Miro, J. M., Alquezar, A., Claramonte, X., García, F., Plana, M., ... Gatell, J. M. (2006). Primary human immunodeficiency virus type 1 infection: Clinical, virological and immunological characteristics of 75 patients (1997-2003). Enfermedades Infecciosas y Microbiología Clínica.
dc.identifier.otherDOI: 10.1016/S0213-005X(06)73769-7
dc.identifier.urihttps://repositorio.huesped.org.ar/handle/123456789/1135
dc.relation.ispartofseriesEnfermedades Infecciosas y Microbiología Clínica
dc.subjectPrimary human immunodeficiency virus type 1 infection
dc.subjectClinical
dc.subjectVirological
dc.subjectImmunological
dc.subjectCharacteristics
dc.subject75 patients
dc.subject1997-2003
dc.titlePrimary human immunodeficiency virus type 1 infection: clinical, virological and immunological characteristics of 75 patients (1997-2003)

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