Host Genetic Factors Associated with Symptomatic Primary HIV Infection and Disease Progression among Argentinean Seroconverters

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dc.contributor.authorColoccini, Romina
dc.contributor.authorDilernia, Dario
dc.contributor.authorGhiglione, Yanina
dc.contributor.authorTurk, Gabriela
dc.contributor.authorLaufer, Natalia
dc.contributor.authorRubio, Andrea
dc.contributor.authorSocias, Maria E.
dc.contributor.authorFigueroa, Maria Ines
dc.contributor.authorSued, Omar
dc.contributor.authorCahn, Pedro
dc.contributor.authorSalomon, Horacio
dc.contributor.authorMangano, Andrea
dc.contributor.authorPando, María Angeles
dc.date.accessioned2024-05-23T15:24:12Z
dc.date.available2024-05-23T15:24:12Z
dc.date.issued2014
dc.description.abstractBackground Variants in HIV-coreceptor C-C chemokine receptor type 5 (CCR5) and Human leukocyte antigen (HLA) genes are the most important host genetic factors associated with HIV infection and disease progression. Our aim was to analyze the association of these genetic factors in the presence of clinical symptoms during Primary HIV Infection (PHI) and disease progression within the first year. Methods Seventy subjects diagnosed during PHI were studied (55 symptomatic and 15 asymptomatic). Viral load (VL) and CD4 T-cell count were evaluated. HIV progression was defined by presence of B or C events and/or CD4 T-cell counts <350 cell/mm3. CCR5 haplotypes were characterized by polymerase chain reaction and SDM-PCR-RFLP. HLA-I characterization was performed by Sequencing. Results Symptoms during PHI were significantly associated with lower frequency of CCR5-CF1 (1.8% vs. 26.7%, p = 0.006). Rapid progression was significantly associated with higher frequency of CCR5-CF2 (16.7% vs. 0%, p = 0.024) and HLA-A*11 (16.7% vs. 1.2%, p = 0.003) and lower frequency of HLA-C*3 (2.8% vs. 17.5%, p = 0.035). Higher baseline VL was significantly associated with presence of HLA-A*11, HLA-A*24, and absence of HLA-A*31 and HLA-B*57. Higher 6-month VL was significantly associated with presence of CCR5-HHE, HLA-A*24, HLA-B*53, and absence of HLA-A*31 and CCR5-CF1. Lower baseline CD4 T-cell count was significantly associated with presence of HLA-A*24/*33, HLA-B*53, CCR5-CF2 and absence of HLA-A*01/*23 and CCR5-HHA. Lower 6-month CD4 T-cell count was associated with presence of HLA-A*24 and HLA-B*53, and absence of HLA-A*01 and HLA-B*07/*39. Moreover, lower 12-month CD4 T-cell count was significantly associated with presence of HLA-A*33, HLA-B*14, HLA-C*08, CCR5-CF2, and absence of HLA-B*07 and HLA-C*07. Conclusion Several host factors were significantly associated with disease progression in PHI subjects. Most results agree with previous studies performed in other groups. However, some genetic factor associations are being described for the first time, highlighting the importance of genetic studies at a local level.
dc.identifier.citationColoccini, R. S., Dilernia, D., Ghiglione, Y., Turk, G., Laufer, N., Rubio, A., ... & Pando, M. Á. (2014). Host genetic factors associated with symptomatic primary HIV infection and disease progression among Argentinean seroconverters. PLOS ONE, 9(11), e113146.
dc.identifier.other10.1371/journal.pone.0113146
dc.identifier.urihttps://repositorio.huesped.org.ar/handle/123456789/1059
dc.relation.ispartofseriesPloS one, 9(11)
dc.subjectGenetic factors
dc.subjectHIV progression
dc.subjectSymptomatic infection
dc.titleHost Genetic Factors Associated with Symptomatic Primary HIV Infection and Disease Progression among Argentinean Seroconverters

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