Biomarkers of Progression after HIV Acute/Early Infection: Nothing Compares to CD4+ T-cell Count?

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dc.contributor.authorTurk, Gabriela
dc.contributor.authorGhiglione, Yanina
dc.contributor.authorHormanstorfer, Macarena
dc.contributor.authorLaufer, Natalia
dc.contributor.authorColoccini, Romina
dc.contributor.authorSalido, Jimena
dc.contributor.authorTrifone, César
dc.contributor.authorRuiz, Maria
dc.contributor.authorFalivene, Juliana
dc.contributor.authorHolgado, María Pía
dc.contributor.authorCaruso, María Paula
dc.contributor.authorFigueroa, María Inés
dc.contributor.authorSalomon, Horacio
dc.contributor.authorGiavedoni, Luis D
dc.contributor.authorDe los Ángeles Pando, María
dc.contributor.authorGherardi, María Magdalena
dc.contributor.authorRabinovich, Roberto Daniel
dc.contributor.authorPury, Pedro A
dc.contributor.authorSued, Omar
dc.date.accessioned2024-05-23T23:50:00Z
dc.date.available2024-05-23T23:50:00Z
dc.date.issued2018-01-13
dc.descriptionFil: Hormanstorfer Y. Fundación Huésped, Buenos Aires; Argentinaes_ES
dc.descriptionFil: Figueroa MI. Fundación Huésped, Buenos Aires; Argentinaes_ES
dc.descriptionFil: Sued O. Fundación Huésped, Buenos Aires; Argentinaes_ES
dc.description.abstractProgression of HIV infection is variable among individuals, and definition disease progression biomarkers is still needed. Here, we aimed to categorize the predictive potential of several variables using feature selection methods and decision trees. A total of seventy-five treatment-naïve subjects were enrolled during acute/early HIV infection. CD4+ T-cell counts (CD4TC) and viral load (VL) levels were determined at enrollment and for one year. Immune activation, HIV-specific immune response, Human Leukocyte Antigen (HLA) and C-C chemokine receptor type 5 (CCR5) genotypes, and plasma levels of 39 cytokines were determined. Data were analyzed by machine learning and non-parametric methods. Variable hierarchization was performed by Weka correlation-based feature selection and J48 decision tree. Plasma interleukin (IL)-10, interferon gamma-induced protein (IP)-10, soluble IL-2 receptor alpha (sIL-2Rα) and tumor necrosis factor alpha (TNF-α) levels correlated directly with baseline VL, whereas IL-2, TNF-α, fibroblast growth factor (FGF)-2 and macrophage inflammatory protein (MIP)-1β correlated directly with CD4+ T-cell activation (p < 0.05). However, none of these cytokines had good predictive values to distinguish “progressors” from “non-progressors”. Similarly, immune activation, HIV-specific immune responses and HLA/CCR5 genotypes had low discrimination power. Baseline CD4TC was the most potent discerning variable with a cut-off of 438 cells/μL (accuracy = 0.93, κ-Cohen = 0.85). Limited discerning power of the other factors might be related to frequency, variability and/or sampling time. Future studies based on decision trees to identify biomarkers of post-treatment control are warrantied.es_ES
dc.formatapplication/pdfes_ES
dc.identifier.doihttps://doi.org/10.3390/v10010034
dc.identifier.urihttps://repositorio.huesped.org.ar/handle/123456789/1414
dc.languageENGes_ES
dc.provenancePublishedes_ES
dc.relation.ispartofseriesViruses;2018, 10(1), 34
dc.rightsopenAccesses_ES
dc.subjectHIVes_ES
dc.subjectBiomarkerses_ES
dc.subjectDisease Progressiones_ES
dc.subjectDecision Treeses_ES
dc.titleBiomarkers of Progression after HIV Acute/Early Infection: Nothing Compares to CD4+ T-cell Count?es_ES
dc.typeArticuloes_ES

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