Tuberculosis in Antiretroviral Treatment Programs in Lower Income Countries: Availability and Use of Diagnostics and Screening

dc.contributor.authorFenner, L.
dc.contributor.authorBallif, M.
dc.contributor.authorGraber, C.
dc.contributor.authorNhandu, V.
dc.contributor.authorDusingize, J. C.
dc.contributor.authorCarriquiry, Gabriela
dc.contributor.authorAnastos, Kathryn
dc.contributor.authorGarone, Daniela
dc.contributor.authorJong, Eefje
dc.contributor.authorGnokoro, Joachim Charles
dc.contributor.authorSued, Omar
dc.contributor.authorAjayi, Samuel
dc.contributor.authorDiero, Lameck
dc.contributor.authorWools-Kaloustian, Kara
dc.contributor.authorKiertiburanakul, Sasisopin
dc.contributor.authorCastelnuovo, Barbara
dc.contributor.authorLewden, Charlotte
dc.contributor.authorNicolas, Durier
dc.contributor.authorSterling, Matthias
dc.contributor.authorEgger, Matthias
dc.contributor.authorCortes, Claudia
dc.date.accessioned2024-05-23T15:24:12Z
dc.date.available2024-05-23T15:24:12Z
dc.date.issued2013
dc.description.abstractObjectives: In resource-constrained settings, tuberculosis (TB) is a common opportunistic infection and cause of death in HIV-infected persons. TB may be present at the start of antiretroviral therapy (ART), but it is often under-diagnosed. We describe approaches to TB diagnosis and screening of TB in ART programs in low- and middle-income countries. Methods and findings: We surveyed ART programs treating HIV-infected adults in sub-Saharan Africa, Asia and Latin America in 2012 using online questionnaires to collect program-level and patient-level data. Forty-seven sites from 26 countries participated. Patient-level data were collected on 987 adult TB patients from 40 sites (median age 34.7 years; 54% female). Sputum smear microscopy and chest radiograph were available in 47 (100%) sites, TB culture in 44 (94%), and Xpert MTB/RIF in 23 (49%). Xpert MTB/RIF was rarely available in Central Africa and South America. In sites with access to these diagnostics, microscopy was used in 745 (76%) patients diagnosed with TB, culture in 220 (24%), and chest X-ray in 688 (70%) patients. When free of charge culture was done in 27% of patients, compared to 21% when there was a fee (p = 0.033). Corresponding percentages for Xpert MTB/RIF were 26% and 15% of patients (p = 0.001). Screening practices for active disease before starting ART included symptom screening (46 sites, 98%), chest X-ray (38, 81%), sputum microscopy (37, 79%), culture (16, 34%), and Xpert MTB/RIF (5, 11%). Conclusions: Mycobacterial culture was infrequently used despite its availability at most sites, while Xpert MTB/RIF was not generally available. Use of available diagnostics was higher when offered free of charge.
dc.identifier.citationFenner, L., Ballif, M., Graber, C., Nhandu, V., Dusingize, J. C., Carriquiry, G., ... & Cortes, C. P. (2013). Tuberculosis in antiretroviral treatment programs in lower income countries: Availability and use of diagnostics and screening. PLOS ONE.
dc.identifier.otherDOI: 10.1371/journal.pone.0077697
dc.identifier.urihttps://repositorio.huesped.org.ar/handle/123456789/1064
dc.relation.ispartofseriesPLoS ONE
dc.subjectTuberculosis diagnostics
dc.subjectAntiretroviral treatment
dc.subjectLow-income countries
dc.titleTuberculosis in Antiretroviral Treatment Programs in Lower Income Countries: Availability and Use of Diagnostics and Screening

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
111_2013_Fenner_Tuberculosis in Antiretroviral Treatment Programs in Lower Income Countries Availability and Use of Diagnostics and Screening.pdf
Size:
621.43 KB
Format:
Adobe Portable Document Format