HIV-1 infected patients older than 50 years. PISCIS cohort study

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dc.contributor.authorNavarro, Gemma
dc.contributor.authorNogueras, Maria M.
dc.contributor.authorSegura, Ferran
dc.contributor.authorCasabona, Jordi
dc.contributor.authorMiro, Jose M.
dc.contributor.authorMurillas, Javier
dc.contributor.authorTural, Cecilio
dc.contributor.authorFerrer, Enrique
dc.contributor.authorJaén, Amelia
dc.contributor.authorForce, Laura
dc.contributor.authorVilaró, Laura
dc.contributor.authorGarcía, Iván
dc.contributor.authorMasabeu, Antoni
dc.contributor.authorAltés, José
dc.contributor.authorEsteve, Albert
dc.contributor.authorSued, Omar
dc.contributor.authorRiera, Maria
dc.contributor.authorClotet, Bonaventura
dc.contributor.authorPodzamczer, Daniel
dc.contributor.authorGatell, Jose
dc.contributor.authorPISCIS Study Group
dc.date.accessioned2024-05-23T18:53:34Z
dc.date.available2024-05-23T18:53:34Z
dc.date.issued2008
dc.description.abstractObjective: The aim of this study is to characterize the ways in which older HIV-infected people differ from younger HIV-infected people. Methods: Prospective cohort study. PISCIS cohort includes newly attended HIV-infected subjects since January 1, 1998. Naive patients were selected. Two groups were defined: G1 (>or=50 years at time of diagnosis, n=493) and G2 (18-49 years, n=4511). Statistical analysis was performed using chi(2), Student's t test, Cox regression and linear mixed models. Results: G1 had different features: males (G1: 84% vs. G2: 75%, p<0.001), sexual transmission (52% vs. 32%, p<0.001), AIDS at first visit (38% vs. 22%, p<0.001). The follow-up was 6 years. Ninety-five percent of patients in G1 and 92% in G2 presented a detectable viral load (>or=500 copies/mm(3)) at the first visit (p=0.016). G1 presented lower CD4 levels with respect to G2 throughout the period but the increase of CD4 in G1 at the end of the study period was 254 cells/mm(3) whereas for G2 it was 196 cells/mm(3) (p<0.001). Mortality was 9% for G1 and 4% for G2 (p<0.001). Conclusions: HIV-infected people diagnosed at the age of 50 years or older showed different features. They showed good viral and immunological response to HAART.
dc.identifier.citationNavarro, G., Nogueras, M. M., Segura, F., Casabona, J., Miro, J. M., Murillas, J., ... Gatell, J. M. (2008). HIV-1 infected patients older than 50 years: PISCIS cohort study. Journal of Infection.
dc.identifier.otherDOI: 10.1016/j.jinf.2008.05.003
dc.identifier.urihttps://repositorio.huesped.org.ar/handle/123456789/1121
dc.relation.ispartofseriesJournal of infection
dc.subjectHIV-1 infected patients
dc.subjectPISCIS cohort study
dc.subjectolder than 50 years
dc.titleHIV-1 infected patients older than 50 years. PISCIS cohort study

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